A Review of Fetal Bovine Serum in the Culture of Mesenchymal Stromal Cells and Potential Alternatives for Veterinary Medicine

A Review of Fetal Bovine Serum in the Culture of Mesenchymal Stromal Cells and Potential Alternatives for Veterinary Medicine

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Fetal bovine serum click here (FBS) remains widely used as a supplement in cell culture media used in the isolation and expansion of mesenchymal stromal cells (MSC) despite longstanding practical, clinical, and ethical concerns over its use.As a result, research on alternative culture media supplement solutions that conserve crucial MSC characteristics has become increasingly relevant.Species-specific supplements and serum-free media such as platelet lysate or chemically defined media have been assessed for their effect in MSC cultures regarding proliferation, differentiation, and immunomodulatory capacity.While none of the alternatives offer a complete solution in replacing traditional FBS supplemented media for culturing MSCs for kt196 torque converter all species, short-term or transitional use of FBS-free media can perform equally well and could address some of the concerns over the use of FBS.